Article
Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort.
EBioMedicine - 1 Oct 2022
Webb Adam J, Harper Emily, Rattay Tim, Aguado-Barrera Miguel E, Azria David, Bourgier Celine, Brengues Muriel, Briers Erik, Bultijnck Renée, Chang-Claude Jenny, Choudhury Ananya, Cicchetti Alessandro, De Ruysscher Dirk, De Santis Maria Carmen, Dunning Alison M, Elliott Rebecca M, Fachal Laura, Gómez-Caamaño Antonio, Gutiérrez-Enríquez Sara, Johnson Kerstie, Lobato-Busto Ramón, Kerns Sarah L, Post Giselle, Rancati Tiziana, Reyes Victoria, Rosenstein Barry S, Seibold Petra, Seoane Alejandro, Sosa-Fajardo Paloma, Sperk Elena, Taboada-Valladares Begoña, Valdagni Riccardo, Vega Ana, Veldeman Liv, Ward Tim, West Catharine M, Symonds R Paul, Talbot Christopher J
Abstract excerpt
BACKGROUND: Circadian rhythm impacts broad biological processes, including response to cancer treatment. Evidence conflicts on whether treatment time affects risk of radiotherapy side-effects, likely because of differing time analyses and target tissues. We previously showed interactive effects of time and genotypes of circadian genes on late toxicity after breast radiotherapy and aimed to validate those results...
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