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An ankylosing spondylitis risk variant alters osteoclast differentiation

19 Sept 2022

Abstract excerpt

OBJECTIVE: To explore whether the variants in non MHC proteasome gene are associated with AS and explain the role of the variant in the disease. MATERIAL AND METHODS: Case-control analysis to identify AS predisposition genes; dual-luciferase reporter assay, immunoblot analysis and osteoclastogenesis assays to detect the function of the positive variant. Affected individuals were diagnosed according to the...

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PMID: 36124946
DOI: 10.1093/rheumatology/keac542

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