Article
Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study.
Medicine - 16 Sept 2022
Saita Kosuke, Sumitani Masahiko, Nishizawa Daisuke, Tamura Takashi, Ikeda Kazutaka, Wakai Kenji, Sudo Yoshika, Abe Hiroaki, Otonari Jun, Ikezaki Hiroaki, Takeuchi Kenji, Hishida Asahi, Tanaka Keitaro, Shimanoe Chisato, Takezaki Toshiro, Ibusuki Rie, Oze Isao, Ito Hidemi, Ozaki Etsuko, Matsui Daisuke, Nakamura Yohko, Kusakabe Miho, Suzuki Sadao, Nakagawa-Senda Hiroko, Arisawa Kokichi, Katsuura-Kamano Sakurako, Kuriki Kiyonori, Kita Yoshikuni, Nakamura Yasuyuki, Momozawa Yukihide, Uchida Kanji
Abstract excerpt
Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants...
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