Article
Systems genomics in age-related macular degeneration.
Experimental eye research - 1 Dec 2022
den Hollander Anneke I, Mullins Robert F, Orozco Luz D, Voigt Andrew P, Chen Hsu-Hsin, Strunz Tobias, Grassmann Felix, Haines Jonathan L, Kuiper Jonas J W, Tumminia Santa J, Allikmets Rando, Hageman Gregory S, Stambolian Dwight, Klaver Caroline C W, Boeke Jef D, Chen Hao, Honigberg Lee, Katti Suresh, Frazer Kelly A, Weber Bernhard H F, Gorin Michael B
Abstract excerpt
Genomic studies in age-related macular degeneration (AMD) have identified genetic variants that account for the majority of AMD risk. An important next step is to understand the functional consequences and downstream effects of the identified AMD-associated genetic variants. Instrumental for this next step are 'omics' technologies, which enable high-throughput characterization and quantification of biological...
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