Different Diabetogenic Response to Moderate Doses of Streptozotocin in Pregnant Rats, and Its Long‐TermConsequences in the Offspring

Abstract excerpt

Diabetes during pregnancy results in congenital malformations and long-term postnatal diseases. Experimental models are still needed to investigate the mechanism responsible for these alterations. Thus, by the administration of different doses of streptozotocin (STZ) (0, 25, 30, or 35 mg/kg body weight, intravenous) at the onset of pregnancy in rats, the present study sought an appropriate animal model for this...

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