Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy.

doi:10.1161/CIRCHEARTFAILURE.116.003565

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Article

Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy.

Circulation. Heart failure - 1 Mar 2017

Coppini Raffaele, Mazzoni Luca, Ferrantini Cecilia, Gentile Francesca, Pioner Josè Manuel, Laurino Annunziatina, Santini Lorenzo, Bargelli Valentina, Rotellini Matteo, Bartolucci Gianluca, Crocini Claudia, Sacconi Leonardo, Tesi Chiara, Belardinelli Luiz, Tardiff Jil, Mugelli Alessandro, Olivotto Iacopo, Cerbai Elisabetta, Poggesi Corrado

Abstract excerpt

BACKGROUND: Current therapies are ineffective in preventing the development of cardiac phenotype in young carriers of mutations associated with hypertrophic cardiomyopathy (HCM). Ranolazine, a late Na+ current blocker, reduced the electromechanical dysfunction of human HCM myocardium in vitro. METHODS AND RESULTS: To test whether long-term treatment prevents cardiomyopathy in vivo, transgenic mice harboring the...

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Identifiers

PMID: 28255011
DOI: 10.1161/CIRCHEARTFAILURE.116.003565
PMCID: PMC6284403

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