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Article

The two-component signal transduction system CopRS of Corynebacterium glutamicum is required for adaptation to copper-excess stress.

PloS one - 1 Jan 2011

Schelder Stephanie, Zaade Daniela, Litsanov Boris, Bott Michael, Brocker Melanie

Abstract excerpt

Copper is an essential cofactor for many enzymes but at high concentrations it is toxic for the cell. Copper ion concentrations ≥50 µM inhibited growth of Corynebacterium glutamicum. The transcriptional response to 20 µM Cu(2+) was studied using DNA microarrays and revealed 20 genes that showed a ≥ 3-fold increased mRNA level, including cg3281-cg3289. Several genes in this genomic region code for proteins...

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Identifiers

PMID: 21799779
DOI: 10.1371/journal.pone.0022143
PMCID: PMC3140484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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