Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions.

doi:10.1007/s00240-022-01360-z

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Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions.

Urolithiasis - 1 Dec 2022

Ali Fahmy T, El-Azeem Eman M Abd, Hekal Hala F A, El-Gizawy Mayada M, Sayed Mohamed S, Mandoh AbdAllah Y, Soliman Ahmed F

Abstract excerpt

Kidney stone disease (KSD) represents an urgent medical problem because of increasing its prevalence. Several functional polymorphisms in genes involved in the renal handling of calcium were associated with KSD pathogenesis. Among those, the rs4236480 of transient receptor potential vanilloid member 5 (TRPV5) gene, the rs1801725 of calcium-sensing receptor (CASR) gene, and the rs1801197 of calcitonin receptor...

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Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Egypt

Genetic Predisposition to Disease

Kidney Calculi

Polymorphism, Single Nucleotide

Receptors, Calcitonin

Receptors, Calcium-Sensing

TRPV Cation Channels

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Identifiers

PMID: 36088585
DOI: 10.1007/s00240-022-01360-z
PMCID: PMC9584976

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