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Article

Common and rare variants associated with kidney stones and biochemical traits.

Nature communications - 14 Aug 2015

Oddsson Asmundur, Sulem Patrick, Helgason Hannes, Edvardsson Vidar O, Thorleifsson Gudmar, Sveinbjörnsson Gardar, Haraldsdottir Eik, Eyjolfsson Gudmundur I, Sigurdardottir Olof, Olafsson Isleifur, Masson Gisli, Holm Hilma, Gudbjartsson Daniel F, Thorsteinsdottir Unnur, Indridason Olafur S, Palsson Runolfur, Stefansson Kari

Abstract excerpt

Kidney stone disease is a complex disorder with a strong genetic component. We conducted a genome-wide association study of 28.3 million sequence variants detected through whole-genome sequencing of 2,636 Icelanders that were imputed into 5,419 kidney stone cases, including 2,172 cases with a history of recurrent kidney stones, and 279,870 controls. We identify sequence variants associating with kidney stones at...

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Identifiers

PMID: 26272126
DOI: 10.1038/ncomms8975
PMCID: PMC4557269

Genes

ALPL
CASR
TRPV5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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