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Decreased Levels of Bisecting GlcNAc Glycoforms of IgG Are Associated with Human Longevity

7 Sept 2010

Abstract excerpt

BACKGROUND: Markers for longevity that reflect the health condition and predict healthy aging are extremely scarce. Such markers are, however, valuable in aging research. It has been shown previously that the N-glycosylation pattern of human immunoglobulin G (IgG) is age-dependent. Here we investigate whether N-linked glycans reflect early features of human longevity. METHODOLOGY/PRINCIPAL FINDINGS: The Leiden...

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PMID: 20830288
DOI: 10.1371/journal.pone.0012566

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