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Article

Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis.

International journal of molecular sciences - 23 Aug 2022

Massarenti Laura, Enevold Christian, Damgaard Dres, Hansen Peter Riis, Frisch Morten, Ødum Niels, Jacobsen Søren, Nielsen Claus Henrik

Abstract excerpt

Epidemiologic studies have shown associations between periodontitis and rheumatoid arthritis (RA), but a causal relationship has not been established. Citrullination of gingival proteins by human peptidylarginine deiminases (PADs) or PAD from Porphyromonas gingivalis has been proposed to generate autoantigens in anti-CCP-positive RA. This study investigated whether the association between periodontitis and RA is...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 36076933
DOI: 10.3390/ijms23179536
PMCID: PMC9455246

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