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Article

Effect of hydroxychloroquine and chloroquine on syncytial differentiation and autophagy in primary human trophoblasts

5 Apr 2022

Abstract excerpt

During placentation, cytotrophoblasts differentiate and fuse to form multinucleated cells (syncytiotrophoblasts) in a process that involves autophagy. Appropriate syncytial differentiation is essential for establishing a healthy pregnancy. In this study, we evaluated the effect of two chloroquine compounds, hydroxychloroquine (HCQ) and chloroquine (CQ), on syncytial differentiation and autophagy in cultured...

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PMID: 36068776
DOI: 10.1016/j.biopha.2022.112916

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