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Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1

5 Sept 2022

Abstract excerpt

Abstract Huntington’s disease is caused by an expanded CAG tract in HTT . The length of the CAG tract accounts for over half the variance in age at onset of disease, and is influenced by other genetic factors, mostly implicating the DNA maintenance machinery. We examined a single nucleotide variant, rs79727797, on chromosome 5 in the TCERG1 gene, previously reported to be associated with Huntington’s disease and...

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PMID: 36064847
DOI: 10.1038/s41525-022-00317-w

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