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Article

Mutations and response to epidermal growth factor receptor inhibitors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2009

Laurent-Puig Pierre, Lievre Astrid, Blons Hélène

Abstract excerpt

Novel therapeutic agents targeting the epidermal growth factor receptor (EGFR) have improved outcomes for a subgroup of patients with colorectal, lung, head and neck, and pancreatic cancers. In these tumors, the EGFR activation turns on at least five different signaling pathways (RAS/mitogen-activated protein kinase, phospholipase C, phosphatidylinositol 3-kinase/AKT, signal transducer and activator of...

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Source

Identifiers

PMID: 19228718
DOI: 10.1158/1078-0432.CCR-08-0905

Genes

EGFR
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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