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Article

Calcium, Its Regulatory Hormones, and Their Causal Role on Blood Pressure: A Two-Sample Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 23 Nov 2022

Giontella Alice, Lotta Luca A, Baras Aris, Minuz Pietro, Gill Dipender, Melander Olle, Fava Cristiano

Abstract excerpt

CONTEXT: Vitamin D (Vit-D), parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23) are the major calciotropic hormones involved in the regulation of blood calcium levels from the intestine, kidney, and bone through a tight endocrine feedback loop system. Altered levels of calcium itself or through the effect of its regulatory hormones could affect blood pressure (BP), but the exact mechanisms remain...

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PMID: 36062972
DOI: 10.1210/clinem/dgac501

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