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Causal effects of serum calcium, phosphate, and 25-hydroxyvitamin D on kidney function: a genetic correlation, pleiotropic analysis, and Mendelian randomization study.

Frontiers in endocrinology - 1 Jan 2024

Liang Yanjun, Liang Shuang, Xie Dayang, Guo Xinru, Yang Chen, Xiao Tuo, Zhuang Kaiting, Xu Yongxing, Wang Yong, Wang Bin, Zhang Zhou, Chen Xiangmei, Chen Yizhi, Cai Guangyan

Abstract excerpt

Background: Existing studies investigating the impact of serum calcium (Ca), phosphate (P), 25 hydroxyvitamin D (25[OH]D), and parathyroid hormone (PTH) levels on kidney function have produced inconsistent results. Further research is needed to establish the direct causal relationship between these factors and kidney function. Methods: The study used genome-wide association study datasets for exposure and...

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Identifiers

PMID: 39403589
DOI: 10.3389/fendo.2024.1348854
PMCID: PMC11471720

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PTH

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