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An integrative pan-cancer analysis revealing the difference in small ring finger family of SCF E3 ubiquitin ligases

18 Aug 2022

Abstract excerpt

Background: The SCF (Skp1-cullin-F-box proteins) complex is the largest family of E3 ubiquitin ligases that mediate multiple specific substrate proteins degradation. Two ring-finger family members RBX1/ROC1 and RBX2/RNF7/SAG are small molecular proteins necessary for ubiquitin ligation activity of the multimeric SCF complex. Accumulating evidence indicated the involvement of RBX proteins in the pathogenesis and...

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PMID: 36059474
DOI: 10.3389/fimmu.2022.968777

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