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Article

Risk-reducing mastectomy decisions among women with mutations in high- and moderate- penetrance breast cancer susceptibility genes.

Molecular genetics & genomic medicine - 1 Oct 2022

Comeaux Jacob G, Culver Julie O, Lee John E, Dondanville Danielle, McArthur Heather L, Quinn Emily, Gorman Nicholas, Ricker Charité, Li Ming, Lerman Caryn

Abstract excerpt

BACKGROUND: Women harboring mutations in breast cancer susceptibility genes are at increased lifetime risk of developing breast cancer and are faced with decisions about risk management, including whether to undergo high-risk screening or risk-reducing mastectomy (RRM). National guidelines recommend BRCA1 or BRCA2 mutation carriers consider RRM, but that carriers of moderate penetrance mutations (e.g., ATM or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36054727
DOI: 10.1002/mgg3.2031
PMCID: PMC9544212

Genes

ATM
BRCA1
BRCA2
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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