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Article

DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy

27 Aug 2022

Abstract excerpt

Loss-of-function mutations in the PRKN, PINK1 and PARK7 genes (encoding parkin, PINK1 and DJ-1, respectively) cause autosomal recessive forms of Parkinson's disease. PINK1 and parkin jointly mediate selective autophagy of damaged mitochondria (mitophagy), but the mechanisms by which loss of DJ-1 induces Parkinson's disease are not well understood. Here, we investigated PINK1/parkin-mediated mitophagy in cultured...

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PMID: 36039535
DOI: 10.1093/brain/awac313

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