Article
UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader.
International journal of molecular sciences - 13 Aug 2022
Cho Jaeyong, Miyagawa Atsushi, Yamaguchi Kazuki, Abe Wakana, Tsugawa Yoji, Yamamura Hatsuo, Imai Takeshi
Abstract excerpt
We previously reported that glucokinase is ubiquitinated and degraded by cereblon with an unknown endogenous glucokinase protein degrader. Here, we show that UDP-glucose is a glucokinase protein degrader. We identified that both glucose and UDP-glucose bind to glucokinase and that both uridine and UDP-glucose bind to cereblon in a similar way to thalidomide. From these results, UDP-glucose was identified as a...
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