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Article

SUMOylation of pancreatic glucokinase regulates its cellular stability and activity.

The Journal of biological chemistry - 22 Feb 2013

Aukrust Ingvild, Bjørkhaug Lise, Negahdar Maria, Molnes Janne, Johansson Bente B, Müller Yvonne, Haas Wilhelm, Gygi Steven P, Søvik Oddmund, Flatmark Torgeir, Kulkarni Rohit N, Njølstad Pål R

Abstract excerpt

Glucokinase is the predominant hexokinase expressed in hepatocytes and pancreatic β-cells, with a pivotal role in regulating glucose-stimulated insulin secretion, illustrated by glucokinase gene mutations causing monogenic diabetes and congenital hyperinsulinemic hypoglycemia. A complex tissue-specific network of mechanisms regulates this enzyme, and a major unanswered question in glucokinase biology is how...

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Identifiers

PMID: 23297408
DOI: 10.1074/jbc.M112.393769
PMCID: PMC3581398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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