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A Computational Approach for Structural and Functional Analyses of Disease-associated Mutations in the Human <i>CYLD</i> Gene

2023-11-17

Abstract excerpt

Tumor suppressor Cylindromatosis protein (CYLD) regulates NF- κB and JNK signaling pathway by cleaving K63 linked poly-ubiquitin chain from its substrate molecules and thus preventing the progression of tumorigenesis and metastasis of the cancer cells. Mutations in CYLD can cause aberrant structure and abnormal functionality leading to tumor formation. In this study, we utilized several computational tools such as...

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Literature Corpus work
13e0733b-2acc-546c-be7c-085968868dc0
DOI
10.1101/2023.11.16.567342
Open publication

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A Computational Approach for Structural and Functional Analyses of Disease-associated Mutations in the Human <i>CYLD</i> GeneDOI 10.1101/2023.11.16.567342
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