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Multicenter clinical radiomics-integrated model based on [18F]FDG PET and multi-modal MRI predict ATRX mutation status in IDH-mutant lower-grade gliomas.

European radiology - 1 Feb 2023

Zhang Liqiang, Pan Hongyu, Liu Zhi, Gao Jueni, Xu Xinyi, Wang Linlin, Wang Jie, Tang Yi, Cao Xu, Kan Yubo, Wen Zhipeng, Chen Jianjun, Huang Dingde, Chen Shanxiong, Li Yongmei

Abstract excerpt

OBJECTIVES: To develop a clinical radiomics-integrated model based on 18 F-fluorodeoxyglucose positron emission tomography ([18F]FDG PET) and multi-modal MRI for predicting alpha thalassemia/mental retardation X-linked (ATRX) mutation status of IDH-mutant lower-grade gliomas (LGGs). METHODS: One hundred and two patients (47 ATRX mutant-type, 55 ATRX wild-type) diagnosed with IDH-mutant LGGs (CNS WHO grades 1 and...

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PMID: 35984514
DOI: 10.1007/s00330-022-09043-4

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