Article
Noninvasive Prediction of IDH1 Mutation and ATRX Expression Loss in Low-Grade Gliomas Using Multiparametric MR Radiomic Features.
Journal of magnetic resonance imaging : JMRI - 1 Mar 2019
Ren Yan, Zhang Xi, Rui Wenting, Pang Haopeng, Qiu Tianming, Wang Jing, Xie Qian, Jin Teng, Zhang Hua, Chen Hong, Zhang Yong, Lu Hongbing, Yao Zhenwei, Zhang Junhai, Feng Xiaoyuan
Abstract excerpt
BACKGROUND: Noninvasive detection of isocitrate dehydrogenase 1 mutation (IDH1(+)) and loss of nuclear alpha thalassemia/mental retardation syndrome X-linked expression ((ATRX(-)) are clinically meaningful for molecular stratification of low-grade gliomas (LGGs). PURPOSE: To study a radiomic approach based on multiparametric MR for noninvasively determining molecular status of IDH1(+) and ATRX(-) in patients with...
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