Article
Recovering individual haplotypes and a contiguous genome assembly from pooled long-read sequencing of the diamondback moth (Lepidoptera: Plutellidae).
G3 (Bethesda, Md.) - 30 Sept 2022
Whiteford Samuel, Van't Hof Arjen E, Krishna Ritesh, Marubbi Thea, Widdison Stephanie, Saccheri Ilik J, Guest Marcus, Morrison Neil I, Darby Alistair C
Abstract excerpt
The assembly of divergent haplotypes using noisy long-read data presents a challenge to the reconstruction of haploid genome assemblies, due to overlapping distributions of technical sequencing error, intralocus genetic variation, and interlocus similarity within these data. Here, we present a comparative analysis of assembly algorithms representing overlap-layout-consensus, repeat graph, and de Bruijn graph...
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