Article
Revealing misassembled segments in the bovine reference genome by high resolution linkage disequilibrium scan.
BMC genomics - 5 Sept 2016
Utsunomiya Adam T H, Santos Daniel J A, Boison Solomon A, Utsunomiya Yuri T, Milanesi Marco, Bickhart Derek M, Ajmone-Marsan Paolo, Sölkner Johann, Garcia José F, da Fonseca Ricardo, da Silva Marcos V G B
Abstract excerpt
BACKGROUND: Misassembly signatures, created by shuffling the order of sequences while assembling a genome, can be detected by the unexpected behavior of marker linkage disequilibrium (LD) decay. We developed a heuristic process to identify misassembly signatures, applied it to the bovine reference genome assembly (UMDv3.1) and presented the consequences of misassemblies in two case studies. RESULTS: We identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.