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Article

Retrotransposition is associated with genome instability during chronological aging.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011

Maxwell Patrick H, Burhans William C, Curcio M Joan

Abstract excerpt

Genetic damage through mutations and genome rearrangements has been hypothesized to contribute to aging. The specific mechanisms responsible for age-induced increases in mutation and chromosome rearrangement frequencies and a potential causative role for DNA damage in aging are under active investigation. Retrotransposons are mobile genetic elements that cause insertion mutations and contribute to genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22021441
DOI: 10.1073/pnas.1100271108
PMCID: PMC3251071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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