Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of Somatic Mutations on Survival Outcomes in Patients With Anaplastic Thyroid Carcinoma.

JCO precision oncology - 1 Aug 2022

Wang Jennifer Rui, Montierth Matthew, Xu Li, Goswami Maitrayee, Zhao Xiao, Cote Gilbert, Wang Wenyi, Iyer Priyanka, Dadu Ramona, Busaidy Naifa L, Lai Stephen Y, Gross Neil D, Ferrarotto Renata, Lu Charles, Gunn Gary Brandon, Williams Michelle D, Routbort Mark, Zafereo Mark E, Cabanillas Maria E

Abstract excerpt

PURPOSE: Anaplastic thyroid carcinoma (ATC) uniformly present with aggressive disease, but the mutational landscape of tumors varies. We aimed to determine whether tumor mutations affect survival outcomes in ATC. MATERIALS AND METHODS: Patients who underwent mutation sequencing using targeted gene panels between 2005 and 2019 at a tertiary referral center were included. Associations between mutation status and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Cancer Diagnosis and Treatment

Share to Thyroid Cancer, Papillary

Share to Thyroid Carcinoma, Anaplastic

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 35977347
DOI: 10.1200/PO.21.00504
PMCID: PMC10530586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of Somatic Mutations on Survival Outcomes in Patients With Anaplastic Thyroid Carcinoma.PMID 35977347Read ↗

Characterization of Driver Mutations in Anaplastic Thyroid Carcinoma Identifies RAS and PIK3CA Mutations as Negative Survival PredictorsSemantic proximity Read ↗

Real-world outcomes and prognostic factors in anaplastic thyroid cancer: evidence from the REGETNE-Thyroid cohort.Semantic proximity Read ↗

Anaplastic thyroid cancer:Improved understanding of what remains a deadly disease.Semantic proximity Read ↗

Comprehensive genomic profiling from C-CAT database unveiled over 80% presence of oncogenic drivers in anaplastic thyroid carcinoma including BRAF, RAS family, NF1, and FGFR1.Semantic proximity Read ↗

Genetic mutations in the treatment of anaplastic thyroid cancer: a systematic review.Semantic proximity Read ↗

Unique mutation patterns in anaplastic thyroid cancer identified by comprehensive genomic profilingSemantic proximity Read ↗

Characterization of Advanced RAS-driven Follicular-derived Thyroid Cancers and Review of Future Therapeutic Avenues.Semantic proximity Read ↗

Prognostic value of genetic mutations in thyroid cancer: a meta-analysis.Semantic proximity Read ↗

Therapeutically Targetable Mutational Landscape of Anaplastic Thyroid Cancer.Semantic proximity Read ↗

Additional Oncogenic Alterations in RAS-Driven Differentiated Thyroid Cancers Associate with Worse Clinicopathologic Outcomes.Semantic proximity Read ↗

Mutational Landmarks in Anaplastic Thyroid Cancer: A Perspective of a New Treatment StrategySemantic proximity Read ↗

Mutational profiling of poorly differentiated and anaplastic thyroid carcinoma by the use of targeted next‐generation sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.