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Mycobacterium abscessus l , d -Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins

1 Aug 2017

Abstract excerpt

ABSTRACT As a growing number of clinical isolates of Mycobacterium abscessus are resistant to most antibiotics, new treatment options that are effective against these drug-resistant strains are desperately needed. The majority of the linkages in the cell wall peptidoglycan of M. abscessus are synthesized by nonclassical transpeptidases, namely, the l , d -transpeptidases. Emerging evidence suggests that these...

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PMID: 28760902
DOI: 10.1128/aac.00866-17

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