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Article

An ENU-induced mutation in the Mertk gene (Mertknmf12) leads to a slow form of retinal degeneration.

Investigative ophthalmology & visual science - 1 Jul 2011

Maddox Dennis M, Hicks Wanda L, Vollrath Douglas, LaVail Matthew M, Naggert Jürgen K, Nishina Patsy M

Abstract excerpt

PURPOSE: To determine the basis and to characterize the phenotype of a chemically induced mutation in a mouse model of retinal degeneration. METHODS: Screening by indirect ophthalmoscopy identified a line of N-ethyl-N-nitrosourea (ENU) mutagenized mice demonstrating retinal patches. Longitudinal studies of retinal histologic sections showed photoreceptors in the peripheral retina undergoing slow, progressive...

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Identifiers

PMID: 21436282
DOI: 10.1167/iovs.10-7077
PMCID: PMC3175976

Genes

TNF

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