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Article

Omicron BA.1 and BA.2 variants increase the interactions of SARS-CoV-2 spike glycoprotein with ACE2.

Journal of molecular graphics & modelling - 1 Dec 2022

Golcuk Mert, Yildiz Ahmet, Gur Mert

Abstract excerpt

SARS-CoV-2 infection is initiated by binding of the receptor-binding domain (RBD) of its spike glycoprotein to the peptidase domain (PD) of angiotensin-converting enzyme 2 (ACE2) receptors in host cells. Recently detected Omicron variant of SARS-CoV-2 (B.1.1.529) is heavily mutated on RBD. First the BA.1 and later the BA.2 variant became the most dominant strains of the Omicron variant. To investigate how the...

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Identifiers

PMID: 35964366
DOI: 10.1016/j.jmgm.2022.108286
PMCID: PMC9352197

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