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Article

Identification of key mutations responsible for the enhancement of receptor-binding affinity and immune escape of SARS-CoV-2 Omicron variant.

Journal of molecular graphics & modelling - 1 Nov 2023

Wang Wei Bu, Ma Yi Bo, Lei Ze Hua, Zhang Xue Feng, Li Jiao, Li Shan Shan, Dong Ze Yuan, Liang Yu, Li Qi Ming, Su Ji Guo

Abstract excerpt

The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised concerns worldwide due to its enhanced transmissibility and immune escapability. The first dominant Omicron BA.1 subvariant harbors more than 30 mutations in the spike protein from the prototype virus, of which 15 mutations are located at the receptor binding domain (RBD). These mutations in the RBD region attracted...

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Identifiers

PMID: 37352723
DOI: 10.1016/j.jmgm.2023.108540
PMCID: PMC10254043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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