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Article

Concordance Between Genomic Alterations Detected by Tumor and Germline Sequencing: Results from a Tertiary Care Academic Center Molecular Tumor Board.

The oncologist - 18 Jan 2023

Green Michelle F, Watson Catherine H, Tait Sarah, He Jie, Pavlick Dean C, Frampton Garrett, Riedel Jinny, Plichta Jennifer K, Armstrong Andrew J, Previs Rebecca A, Kauff Noah, Strickler John H, Datto Michael B, Berchuck Andrew, Menendez Carolyn S

Abstract excerpt

OBJECTIVE: The majority of tumor sequencing currently performed on cancer patients does not include a matched normal control, and in cases where germline testing is performed, it is usually run independently of tumor testing. The rates of concordance between variants identified via germline and tumor testing in this context are poorly understood. We compared tumor and germline sequencing results in patients with...

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Identifiers

PMID: 35962742
DOI: 10.1093/oncolo/oyac164
PMCID: PMC9847540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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