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Article

LRP6 β-Propeller Destabilization: Novel Variant, Phenotype and Diagnostic Implications in Tooth Agenesis.

International dental journal - 1 Apr 2026

Intarak Narin, Ghasemnejad Tohid, Fakhruddin Kausar Sadia, Kamal Ayaana, Prommanee Sasiprapa, Jahanian Khadijeh Hoda, Lovell Nigel H, Alinejad-Rokny Hamid, Porntaveetus Thantrira

Abstract excerpt

BACKGROUND AND OBJECTIVES: Oligodontia, the congenital absence of multiple permanent teeth, is frequently linked to LRP6 variants. However, the genotype-phenotype correlations remain unclear and non-European cohorts are underrepresented. The objectives of this study were to: (1) characterize the molecular and clinical features of LRP6 variants identified in unrelated Thai individuals with tooth agenesis; (2)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41505923
DOI: 10.1016/j.identj.2025.109367
PMCID: PMC12808960

Genes

LRP6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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