The Potential Roles of Endogenous Retroviruses in Autoimmunity

Abstract excerpt

Endogenous retroviruses (ERVs) are estimated to comprise up to 1% of human DNA. While the genome of many ERVs is interrupted by termination codons, deletions or frame shift mutations, some ERVs are transcriptionally active and recent studies reveal protein expression or particle formation by human ERVs. ERVs have been implicated as aetiological agents of autoimmune disease, because of their structural and...

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• T-cell and B-cell Immunology
• T-cell and Retrovirus Studies
• Viral-associated cancers and disorders