Article

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation

2026-07-16

Abstract excerpt

Tioxazafen is an effective nematicide whose commercialization was halted because handlers reportedly developed rashes after working with seeds coated with a tioxazafen-laced cocktail. Here, we show that tioxazafen is bioactivated into toxic products by nematode and human cytochrome P450s. Through systematic analyses, we found that bioactivated tioxazafen disrupts proteasome function, leading to the accumulation of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0b6981c-2f22-58a1-861b-02aafb2197d8
DOI: 10.64898/2026.07.10.737828

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 BioactivationDOI 10.64898/2026.07.10.737828Read

Unveiling the Impacts of Glyphosate, Deltamethrin, Propamocarb and Tebuconazole on Gut HealthSemantic proximity Read

Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugsSemantic proximity Read

Deciphering the intricacies of chlorantraniliprole, azadirachtin and uniconazole interactions with fall armyworm in maize: a comprehensive analysis through transcriptomic and metabolomic profilingSemantic proximity Read

Bixafen, a succinate dehydrogenase inhibitor fungicide, causes microcephaly and motor neuron axon defects during developmentSemantic proximity Read

The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C. elegans.Semantic proximity Read

Susceptibility monitoring and the molecular characterization of resistance of <i>Spodoptera frugiperda</i> (Lepidoptera: Noctuidae) to lambda-cyhalothrin and chlorpyrifosSemantic proximity Read

The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in <i>C. elegans</i>Semantic proximity Read

Pesticides Could Alter Amphibian Skin Microbiomes and the Effects of Batrachochytrium dendrobatidisSemantic proximity Read

Multi-omics phenotyping of the gut-liver axis allows health risk predictability from <i>in vivo</i> subchronic toxicity tests of a low-dose pesticide mixtureSemantic proximity Read

Sublethal effects of typical neonicotinoids exposure on Drosophila melanogaster: Insights from phenotypic abnormalities to molecular mechanisms.Semantic proximity Read

Contribution of multiple overexpressed carboxylesterase genes to indoxacarb resistance in <scp><i>Spodoptera litura</i></scp>Semantic proximity Read

Partitioning the roles of CYP6G1 and gut microbes in the metabolism of the insecticide imidacloprid in Drosophila melanogaster.Semantic proximity Read