Enhancing thalassemia carrier detection: Advancing genetic screening strategies in prenatal care

Abstract excerpt

The carrier rates of alpha- and beta-thalassemia are notably high in certain regions. Current screening methods using traditional mean corpuscular volume (MCV) measurements can prevent the birth of severe cases of thalassemia, but often miss carriers of mild forms, potentially leading to hemoglobin H disease or thalassemia in their offspring. This study aimed to demonstrate that genetic carrier screening using...

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