Article
Combined Gap-Polymerase Chain Reaction and Targeted Next-Generation Sequencing Improve α- and β-Thalassemia Carrier Screening in Pregnant Women in Vietnam.
Hemoglobin - 1 Jul 2022
Lam Tuan-Thanh, Nguyen Doan-Tu, Le Quang Thanh, Nguyen Duy-Anh, Hoang Diem-Tuyet Thi, Nguyen Huu Du, Nguyen Canh Chuong, Doan Kim Phuong Thi, Tran Nhat-Thang, Ha Thi Minh Thi, Trinh Thu Huong Nhat, Nguyen Van Thong, Lam Duc Tam, Le Minh Tam, Nguyen Xuan Thao, Ho Thu-Hang Thi, Tran Trung Hoanh, Ho Viet Thang, Bui Thanh Van, Nguyen Van Trong, Hoang Phuoc Ba, Nguyen Hoai Thanh, Nguyen Manh Hoan, Vo Thanh-Binh, Le Duy-Khang Nguyen, Truong Thao Ngoc, Dao Hong-Thuy Thi, Vo Phuong-Anh Ngoc, Nguyen Thien-Chi Van, Tran Ngoc-Nhu Thi, Tran Quynh-Nhu Thi, Van Yen-Linh Thi, Nguyen Thanh-Thanh Thi, Huynh Bich-Ngoc Thi, Nguyen Thanh-Phuong Thi, Tran Kim-Van Thi, Nguyen Cong-Trai, Doan Phuoc-Loc, Nguyen Thanh-Dat, Do Thanh-Thuy Thi, Truong Dinh-Kiet, Tang Hung Sang, Cao Ngoc-Phuong Thi, Phan Minh-Duy, Giang Hoa, Nguyen Hoai-Nghia
Abstract excerpt
Vietnam has a high thalassemia burden. We collected blood samples from 5880 pregnant Vietnamese women during prenatal health checks to assess thalassemia carrier frequency using combined gap-polymerase chain reaction (gap-PCR) and targeted next-generation sequencing (NGS). Thalassemia carriers were identified with prevalence of 13.13% (772), including 7.82% (460) carriers of α-thalassemia (α-thal), 5.31% (312)...
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