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Article

Non‑invasive prenatal diagnosis of thalassemia through multiplex PCR, target capture and next‑generation sequencing.

Molecular medicine reports - 1 Aug 2020

Yang Xu, Ye Yanchou, Fan Dongmei, Lin Sheng, Li Ming, Hou Hongying, Zhang Jun, Yang Xuexi

Abstract excerpt

Prenatal clinical detection of thalassemia involves gap‑PCR and reverse dot blot (RDB) analysis of fetal DNA acquired through invasive methods. The present study aimed to develop a non‑invasive prenatal diagnostic method for thalassemia based on next‑generation sequencing (NGS). A total of eight families with proband children with thalassemia were recruited for the study during a subsequent pregnancy. The...

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Source

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Identifiers

PMID: 32627040
DOI: 10.3892/mmr.2020.11234
PMCID: PMC7339645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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