Atezolizumab, vemurafenib, and cobimetinib in patients with melanoma with CNS metastases (TRICOTEL): a multicentre, open-label, single-arm, phase 2 study.

doi:10.1016/S1470-2045(22)00452-1

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Article

Atezolizumab, vemurafenib, and cobimetinib in patients with melanoma with CNS metastases (TRICOTEL): a multicentre, open-label, single-arm, phase 2 study.

The Lancet. Oncology - 1 Sept 2022

Dummer Reinhard, Queirolo Paola, Abajo Guijarro Ana Maria, Hu Youyou, Wang Dao, de Azevedo Sergio Jobim, Robert Caroline, Ascierto Paolo Antonio, Chiarion-Sileni Vanna, Pronzato Paolo, Spagnolo Francesco, Mujika Eizmendi Karmele, Liszkay Gabriella, de la Cruz Merino Luis, Tawbi Hussein

Abstract excerpt

BACKGROUND: Targeted therapy and immunotherapy have shown intracranial activity in melanoma with CNS metastases, but there remains an unmet need, particularly for patients with symptomatic CNS metastases. We aimed to evaluate atezolizumab in combination with cobimetinib or vemurafenib plus cobimetinib in patients with melanoma with CNS metastases. METHODS: TRICOTEL was a multicentre, open-label, single-arm, phase...

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PMID: 35940183
DOI: 10.1016/S1470-2045(22)00452-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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