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Article

Phase 1b study of cobimetinib plus atezolizumab in patients with advanced BRAFV600 wild-type melanoma progressing on prior anti-programmed death-1 therapy.

European journal of cancer (Oxford, England : 1990) - 1 Jan 2023

Sandhu Shahneen, Atkinson Victoria, Cao Maria González, Medina Theresa, Rivas Ainara Soria, Menzies Alexander M, Caro Ivor, Roberts Louise, Song Yuyao, Yan Yibing, Guo Yu, Xue Cloris, Long Georgina V

Abstract excerpt

OBJECTIVE: To evaluate the efficacy and safety of cobimetinib plus atezolizumab in the treatment of patients with advanced BRAFV600 wild-type melanoma who had progressed on prior anti‒programmed death-1 (PD-1) therapy. PATIENTS AND METHODS: This phase 1b, open-label, international multicentre study enrolled 3 cohorts. Herein, we report on patients in cohorts A and B who had progressed on prior anti‒PD-1 therapy....

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PMID: 36455412
DOI: 10.1016/j.ejca.2022.10.019

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