Effectiveness, safety and utilization of cobimetinib and vemurafenib in patients with BRAF V600 mutant melanoma with and without cerebral metastasis under real-world conditions in Germany: the non-interventional study coveNIS.

doi:10.1097/CMR.0000000000000908

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Effectiveness, safety and utilization of cobimetinib and vemurafenib in patients with BRAF V600 mutant melanoma with and without cerebral metastasis under real-world conditions in Germany: the non-interventional study coveNIS.

Melanoma research - 1 Feb 2024

Kähler Katharina C, Debus Dirk, Schley Gaston, Göppner Daniela, Hassel Jessica C, Meier Friedegund, Terheyden Patrick, Stadler Rudolf, Tüting Thomas, Kaatz Martin, Hoff Norman-Philipp, Masoudi Ehsan, Zdanowicz-Specht Agnieszka, Nguyen Minh Tam, Mohr Peter

Abstract excerpt

Cobimetinib/vemurafenib combination therapy is approved for treatment of adults with unresectable or metastatic BRAF V600 mutated malignant melanoma (mM). The non-interventional post-authorisation safety study coveNIS collected real-world data on cobimetinib/vemurafenib treatment focussing on overall survival (OS), safety and utilization. MM patients with brain metastases are usually excluded from clinical...

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PMID: 37962220
DOI: 10.1097/CMR.0000000000000908
PMCID: PMC10732299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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