Article
Local Therapy for Oligoprogression or Consolidation in High Mutational Burden Stage 4 Colorectal Cancer Treated With PD-1 or PD-L1 Blockade.
Annals of surgical oncology - 1 Dec 2022
Klemen Nicholas D, Court Colin M, Fernandes Maria Clara, Walch Henry S, Chatila Walid K, Saadat Lily V, Maron Steven, Crane Chris, Shia Jinru, Cercek Andrea, Gönen Mithat, Schultz Nikolaus D, Garcia Aguilar Julio, Jarnagin William R, D'Angelica Michael I
Abstract excerpt
BACKGROUND: Immune checkpoint blockade (ICI) of programmed cell death protein 1 (PD-1) or PD-1 ligand (PD-L1) can induce durable responses in patients who have colorectal cancer (CRC) with a high tumor mutational burden (TMB). Two recurring clinical dilemmas show how to manage oligoprogressive disease and stable disease after ICI. METHODS: A cohort study was conducted to analyze patients with metastatic CRC who...
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