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Effect of Liver Metastases on Survival in Microsatellite-Stable Metastatic Colorectal Cancer Treated with Immune Checkpoint Inhibitors.

Cancer research communications - 1 Feb 2026

Pakvisal Nussara, Pappas Leontios, Caughey Bennett A, Horick Nora K, Tarazona Noelia, Vora Kruti B, Ouyang Ben, Pandey Aditya, Peacker Bryan L, Sun Joie, Zubiri Leyre, Reynolds Kerry L, Ryan David P, Qadan Motaz, Corcoran Ryan B, Giantonio Bruce, Allen Jill N, Walsh Elizabeth P, Clark Jefferey W, Ting David T, Parikh Aparna R

Abstract excerpt

Immune checkpoint inhibitors (ICI) have limited efficacy in microsatellite-stable (MSS) metastatic colorectal cancer (mCRC), potentially because of immunosuppressive mechanisms associated with liver metastases. The impact of liver metastases on survival outcomes was evaluated in a retrospective cohort of patients with MSS mCRC treated with ICI-based therapies at Mass General Brigham between January 2015 and...

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Identifiers

PMID: 41615712
DOI: 10.1158/2767-9764.CRC-25-0690
PMCID: PMC13038315

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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