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Article

MHC class II genotype-by-pathogen genotype interaction for infection prevalence in a natural rodent-Borrelia system.

Evolution; international journal of organic evolution - 1 Sept 2022

Råberg Lars, Clough Dagmar, Hagström Åsa, Scherman Kristin, Andersson Martin, Drews Anna, Strandh Maria, Tschirren Barbara, Westerdahl Helena

Abstract excerpt

MHC genes are extraordinarily polymorphic in most taxa. Host-pathogen coevolution driven by negative frequency-dependent selection (NFDS) is one of the main hypotheses for the maintenance of such immunogenetic variation. Here, we test a critical but rarely tested assumption of this hypothesis-that MHC alleles affect resistance/susceptibility to a pathogen in a strain-specific way, that is, there is a host...

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Identifiers

PMID: 35909235
DOI: 10.1111/evo.14590
PMCID: PMC9541904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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