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Replication Study for the Association of Five SNPs Identified by GWAS and Trastuzumab-Induced Cardiotoxicity in Japanese and Singaporean Cohorts.

Biological & pharmaceutical bulletin - 1 Jan 2022

Udagawa Chihiro, Kuah Sherwin, Shimoi Tatsunori, Kato Ken, Yoshida Teruhiko, Nakano Mari Hara, Shimo Arata, Kojima Yasuyuki, Yoshie Reiko, Tsugawa Koichiro, Mushiroda Taisei, Tan Ern Yu, Zembutsu Hitoshi

Abstract excerpt

Trastuzumab (herceptin) is an effective drug for human epidermal growth factor receptor type 2 (HER2)-positive cancer. However, cardiotoxicity remains a serious complication. In our previous genome-wide association study (GWAS), we identified potential associations for five single nucleotide polymorphisms (SNPs) with trastuzumab-induced cardiotoxicity in a Japanese population. To validate this association, here...

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Identifiers

PMID: 35908902
DOI: 10.1248/bpb.b22-00136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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