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Article

Whole exome sequencing to identify genetic markers for trastuzumab-induced cardiotoxicity.

Cancer science - 1 Feb 2018

Udagawa Chihiro, Nakamura Hiromi, Ohnishi Hiroshi, Tamura Kenji, Shimoi Tatsunori, Yoshida Masayuki, Yoshida Teruhiko, Totoki Yasushi, Shibata Tatsuhiro, Zembutsu Hitoshi

Abstract excerpt

Although trastuzumab-induced cardiotoxicity is an important determinant to limit the use of this drug, the molecular mechanism of risk for this toxicity is not well understood. To identify genetic variants determining the risk of trastuzumab-induced cardiotoxicity, we carried out whole exome sequencing of germline DNA samples from 9 patients with trastuzumab-induced cardiotoxicity, and conducted a case-control...

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Identifiers

PMID: 29247589
DOI: 10.1111/cas.13471
PMCID: PMC5797809

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EYS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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