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Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance

30 Jul 2022

Abstract excerpt

Abstract Acquired resistance to cetuximab in colorectal cancers is partially mediated by the acquisition of mutations located in the cetuximab epitope in the epidermal growth factor receptor (EGFR) ectodomain and hinders the clinical application of cetuximab. We develop a structure-guided and phage-assisted evolution approach for cetuximab evolution to reverse EGFR S492R - or EGFR G465R -driven resistance without...

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PMID: 35907884
DOI: 10.1038/s41467-022-32159-6

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