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Article

[Experimental and computational analyses of altered cetuximab binding induced by EGFR mutations].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 25 Aug 2026

Li Yifan, Yang Haotong, Zhu Jianwei, Wu Mingyuan

Abstract excerpt

Acquired mutations in the extracellular domain of epidermal growth factor receptor (EGFR) are major causes of cetuximab resistance. However, the structural mechanisms by which different mutations impair antibody binding remain to be clarified. In this study, four clinically reported EGFR mutations, S492R, G465R, S464L, and I491M, were selected for investigation. Corresponding mutant EGFR fusion proteins were...

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Share to Antineoplastic Agents, Immunological
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42638061
DOI: 10.13345/j.cjb.260294

Genes

EGFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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