Article
A Novel Cartesian Plot Analysis for Fixed Monolayers That Relates Cell Phenotype to Transfer of Contents between Fibroblasts and Cancer Cells by Cell-Projection Pumping.
International journal of molecular sciences - 19 Jul 2022
Mahadevan Swarna, Kwong Kenelm, Lu Mingjie, Kelly Elizabeth, Chami Belal, Romin Yevgeniy, Fujisawa Sho, Manova Katia, Moore Malcolm A S, Zoellner Hans
Abstract excerpt
We recently described cell-projection pumping as a mechanism transferring cytoplasm between cells. The uptake of fibroblast cytoplasm by co-cultured SAOS-2 osteosarcoma cells changes SAOS-2 morphology and increases cell migration and proliferation, as seen by single-cell tracking and in FACS separated SAOS-2 from co-cultures. Morphological changes in SAOS-2 seen by single cell tracking are consistent with...
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